Transcription profiling by array of human breast cancers after treatment with progesterone or progesterone and bisphenol A

ABSTRACT: Breast cancer outcome is highly variable. Whether inadvertent exposure to environmental xenobiotics evokes a biological response promoting cancer aggressiveness and a higher probability of tumor recurrence remains unknown. To determine specific molecular alterations, which arise in high-risk breast tissue in the presence of the ubiquitous xenoestrogen, bisphenol A (BPA), we employed non-malignant random periareolar fine needle aspirates (RPFNA) in a novel functional assay. Early events induced by BPA in epithelial-stromal cocultures derived from the contralateral tissue of breast cancer patients included gene expression patterns, which facilitate apoptosis evasion, endurance of microenvironmental stress, and cell cycle deregulation without a detectable increase in cell number. This BPA res

ORGANISM(S): Homo sapiens

SUBMITTER: Dairkee SH 

PROVIDER: S-ECPF-GEOD-10270 | biostudies-other | 2008 Apr

REPOSITORIES: biostudies-other