Transcription profiling of human multifocal lesions from patients with in-transit extremity melanoma to determine if gene expression is hetereogenous in all lesions

ABSTRACT: An evaluation of multifocal lesions from patients with in-transit extremity melanoma to determine if all lesions from a patient harbor homogeneous patterns of gene expression; Gene expression profiling studies can help guide treatment for cancer patients by providing tools in the form of gene-expression signatures to characterize a tumor in terms of underlying biology, predicted response to therapy, metastatic progression and/or recurrence. The utility of gene signatures for defining therapeutic strategies in the treatment of extremity in-transit melanoma will be dependent on the genetic relationship between the multifocal lesions typically present in this disease and the extent to which a single lesion is representative of residual tumor burden. Using microarray-based gene expression pr

ORGANISM(S): Homo sapiens

SUBMITTER: Augustine Christina 

PROVIDER: S-ECPF-GEOD-10282 | biostudies-other |

REPOSITORIES: biostudies-other