Transcription profiling by array of human hormone-responsive MCF-7 cells versus estrogen-deprived breast cancer cells

ABSTRACT: Estrogen deprivation using aromatase inhibitors is currently the standard of care for patients with estrogen-receptor (ER)-positive breast cancer. Unfortunately, prolonged estrogen deprivation leads to drug resistance (i.e. hormone-independent growth). We therefore used DNA microarray analysis to study the gene expression profiles of wild-type MCF-7 cells (which are sensitive to antihormone therapy) and long-term estrogen deprived MCF-7:5C and MCF-7:2A breast cancer cells (which are resistance to estrogen-deprivation; aromatase inhibitor resistant). Transcriptional profiling of wild-type MCF-7 cells and estrogen deprived MCF-7:5C and MCF-7:2A cells was performed using Affymetrix Human Genome U133 Plus 2.0 Array. Experiment Overall Design: We wanted to study the gene expression profiles of

ORGANISM(S): Homo sapiens

SUBMITTER: Lewis-Wambi Dr Joan 

PROVIDER: S-ECPF-GEOD-10879 | biostudies-other |

REPOSITORIES: biostudies-other