Transcription profiling by array of human breast cancer cell lines after treatment with miR-221/222 mimics or inhibitors

ABSTRACT: mRNA breast cancer cell lines were profiled to study the function of hsa-mir-221 and hsa-mir-222. MCF7 cell lines were profiled after treatment with mir-221/222 mimics, and compared to profiles with transfection controls. Similarly, MDA-MB-231 cell lines were profiled after treatment with mir-221/222 inhibitors, and compared to profiles with transfection controls. Since ESR1 is a predicted target of mir-221/222 we also profiled MCF7 cell lines after disrupting ESR1 with an siRNA. Other breast cancer cell lines are provided because all cell lines were normalized together. Experiment Overall Design: mRNA breast cancer cell line profiles with some samples in duplicate or triplicate. See summary for more information.

ORGANISM(S): Homo sapiens

SUBMITTER: Adai Alex 

PROVIDER: S-ECPF-GEOD-10890 | biostudies-other |

REPOSITORIES: biostudies-other