Molecular Classification and Prediction of Survival in Non-Small-Cell Lung Cancer

ABSTRACT: BACKGROUND: Global gene expression analysis provides a comprehensive molecular characterization of non-small cell lung cancer. The aim of this study was to evaluate the feasibility of integrating expression profiling into routine clinical work-up by including minute bronchoscopic biopsies and develop a robust prognostic gene expression signature METHODS: Tissue samples from a series of 41 chemotherapy-naïve non-small cell lung cancer patients and 15 control patients with inflammatory lung diseases were obtained during routine clinical work-up and gene expression profiles were gained using a highly sensitive oligonucleotide array platform (Novachip ; 34'207 transcripts). Gene expression signatures were analyzed by correlation with histological and clinical parameters and validated on indepe

ORGANISM(S): Homo sapiens

SUBMITTER: Baty F 

PROVIDER: S-ECPF-GEOD-11117 | biostudies-other | 2010 Jan

REPOSITORIES: biostudies-other