Transcription profiling of human breast cancer cohort reveals the humoral immune system has a key prognostic impact in node-negative breast cancer

ABSTRACT: Estrogen receptor (ER) expression and proliferative activity are established prognostic factors in breast cancer. In a search for additional prognostic motives we analyzed the gene expression patterns of 200 tumors of patients who were not treated by systemic therapy after surgery using a discovery approach. After performing hierarchical cluster analysis, we identified co-regulated genes related to the biological process of proliferation, steroid hormone receptor expression, as well as B cell and T cell infiltration. We calculated metagenes as surrogate for all genes contained within a particular cluster and visualized the relative expression in relation to time to metastasis with principal component analysis. Distinct patterns led to the hypothesis of a prognostic role of the immune syste

ORGANISM(S): Homo sapiens

SUBMITTER: Schmidt M 

PROVIDER: S-ECPF-GEOD-11121 | biostudies-other | 2008 Jul

REPOSITORIES: biostudies-other