Transcription profiling by array of human MCF cells treated with estrogen

ABSTRACT: The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. Combining this unique resource with gene expression data demonstrates distinct temporal mechanisms of estrogen-mediated gene regulation,particularly in the case of estrogen-suppressed genes. Furthermore, this resource has allowed the identification of cis-regulatory sites in previously unexplored regions of the genome and the cooperating transcription factors underlying estrogen signaling in breast cancer. Experiment Overall Design: This Series currently contains the gene e

ORGANISM(S): Homo sapiens

SUBMITTER: Carroll JS 

PROVIDER: S-ECPF-GEOD-11324 | biostudies-other | 2006 Nov

REPOSITORIES: biostudies-other