P53-repressed miRNAs are Involved with E2F in a Feed Forward Loop Promoting Proliferation

ABSTRACT: Analysis of miRNA expression in human breast cancer samples with Agilent's miRNA arrays. These samples are part of a study where we have investigated the mammalian cell proliferation control network consisting of transcription regulators, E2F and p53, their targets, and a family of 14 microRNAs. We observed that indicative of their significance, expression of these microRNAs is down-regulated in senescent cells and in breast cancers harboring wild-type p53. These microRNAs are repressed by p53 in an E2F1-mediated manner. Abstract of paper: Normal cell growth is governed by a complicated biological system, featuring multiple levels of control, often deregulated in cancers. The role of microRNAs in the control of gene expression is now increasingly appreciated, yet their involvement in cont

ORGANISM(S): Homo sapiens

SUBMITTER: Brosh R 

PROVIDER: S-ECPF-GEOD-12848 | biostudies-other | 2008

REPOSITORIES: biostudies-other