Transcription profiling of human juvenile pilocytic astrocytomas reveals two potential subgroups

ABSTRACT: Juvenile pilocytic astrocytoma (JPA) is one of the most common brain tumors in children. The expression profiles of 21 JPAs, determined using Affymetrix GeneChip U133A, were compared with subjects with normal cerebella. The genes involved in neurogenesis, cell adhesion, synaptic transmission, central nervous system development, potassium ion transport, protein dephosphorylation, and cell differentiation were found to be significantly deregulated in JPA. These 21 JPAs were further clustered into two major groups by unsupervised hierarchical clustering using a set of 848 genes with high covariance (0.5-10). Supervised analysis with Significance Analysis of Microarrays software between these two potential subgroups identified a list of significant differentially expressed genes involved in ce

ORGANISM(S): Homo sapiens

SUBMITTER: Wong KK 

PROVIDER: S-ECPF-GEOD-12907 | biostudies-other | 2005 Jan

REPOSITORIES: biostudies-other