Candidate genes for the recurrence of glioblastoma multiforme identified by microarray

ABSTRACT: Background: Glioblastoma multiforme (GBM) is the most aggressive and most lethal primary malignant brain tumor, correlated with survival rates of less than one year from the time of diagnosis. Current surgical procedure attempts to remove the bulk of the tumor mass, whereas GBM frequently recurs within 1-3cm from the primary tumor resection site. Molecular mechanisms involved in the recurrence of the tumor are still poorly understood. The aim of the study was to define the molecular signature of GBM surrounding white matter (WM) in order to better understand the molecular mechanisms involved with tumor relapse. Material & Methods: Human GBM tumor bulk and surrounding tissue (1-3cm from the border of the tumor) were obtained from five patients who underwent total tumour resection, while no

ORGANISM(S): Homo sapiens

SUBMITTER: Mangiola A 

PROVIDER: S-ECPF-GEOD-13276 | biostudies-other | 2013

REPOSITORIES: biostudies-other