Mechanism and transcriptional program of YB-1 in breast cancer cell lines

ABSTRACT: YB-1 controls epithelial-mesenchymal transitions by restricting translation of growth-related mRNAs and enabling expression of EMT-inducing transcription factors. We used microarrays to characterize the direct transcriptional and indirect translational regulation of mRNAs by exogenous YB-1 in breast cancer cell lines. Keywords: gene expression profiling To evaluate this in a genome-wide manner we compared microarray expression profiles of total mRNA and mRNAs isolated from Ps (translationally active) or post-Ps (translationally inactive) fractions of MCF10AT-MSCV vs. MCF10AT-YB-1 cells

ORGANISM(S): Homo sapiens

SUBMITTER: Evdokimova V 

PROVIDER: S-ECPF-GEOD-13410 | biostudies-other | 2009 May

REPOSITORIES: biostudies-other