Multiple Salivary Biomarkers for Early Detection of Pancreatic Cancer

ABSTRACT: Pancreatic cancer is the fourth leading cause of cancer death. Lack of early detection technology for pancreatic cancer invariably leads to a typical clinical presentation of incurable disease at initial diagnosis. Oral fluid (saliva) meets the demand for non-invasive, accessible, and highly efficient diagnostic medium. The level of salivary analytes, such as mRNA and microflora, vary upon disease onset; thus possess valuable signatures for early detection and screening. In this study, we evaluated the performance and translational utilities of the salivary transcriptomic and microbial biomarkers for non-invasive detection of early pancreatic cancer. Two biomarker discovery technologies were used to profile transcriptome in saliva supernatant and microflora in saliva pellet. The Affymetrix

ORGANISM(S): Homo sapiens

SUBMITTER: Zhang L 

PROVIDER: S-ECPF-GEOD-14245 | biostudies-other | 2010 Mar

REPOSITORIES: biostudies-other