The gamma secretase inhibitor LLNle induces apoptosis of human GBM tumor initiating cells

ABSTRACT: Glioblastomas (GBM) are poorly differentiated astrocytic tumors arising in the Central Nervous System (CNS), which despite aggressive treatments are still characterized by a fatal outcome. Several studies have shown the existence of a subpopulation of cells within glioma tumors displaying cancer stem cells properties. As the term “tumor initiating cells” (TICs) is frequentely used to describe cells as these with cancer stem cells capacity. Because TICs promotes the tumor chemo- and radio-resistance and angiogenesis it is conceivable that finding a mean to kill these cells would lead to a better therapy for GBM. The NOTCH gene has an important role during the CNS development, in the maintenance of dividing cells in promoting neural lineage entry of Embryonic Stem Cells and the differentiati

ORGANISM(S): Homo sapiens

SUBMITTER: Monticone M 

PROVIDER: S-ECPF-GEOD-14581 | biostudies-other | 2009 Nov

REPOSITORIES: biostudies-other