Transcript expression data from glioblastoma subcutaneous xenografts and non-neoplastic control brain

ABSTRACT: Development of model systems that recapitulate the molecular heterogeneity observed amongst GBM tumors will expedite the testing of targeted molecular therapeutic strategies for GBM treatment. In this study, we profiled DNA copy number and mRNA expression in 21 independent GBM tumor lines maintained as subcutaneous xenografts (GBMX), and compared GBMX molecular signatures to those observed in GBM clinical specimens derived from The Cancer Genome Atlas (TCGA). The predominant copy number signature in both tumor groups was defined by chromosome-7-gain/chromosome-10-loss, a poor prognosis genetic signature. We also observed, at frequencies similar to that detected in TCGA GBMs genomic amplification and overexpression of known GBM oncogenes such as EGFR, MDM2, CDK6 and MYCN, and novel genes in

ORGANISM(S): Homo sapiens

SUBMITTER: Hodgson JG 

PROVIDER: S-ECPF-GEOD-14805 | biostudies-other | 2009 Oct

REPOSITORIES: biostudies-other