Gene-level expression data in melanocytes and in melanoma cell lines WM1552C and A375 over-expressing miR211

ABSTRACT: MicroRNAs (miRNAs) influence cancer development through post-transcriptional negative regulation of both tumor suppressors and oncogenes. We subjected melanoma cell lines, normal melanocytes, and keratinocytes to array based miRNA profiling, and identified several distinct miRNAs with differential expression. Specifically, miR-211 levels were depleted in all eight melanoma cell lines examined, and also in 23 of 30 distinct patient melanoma samples (graded as primary in situ, regional metastatic, distant metastatic and nodal metastatic). Putative target genes of miR-211 were identified, and their anticipated increased expression levels were confirmed in melanoma cell lines, which were reduced in two melanoma cell lines that artificially over-expressed miR-211. Four such target genes (TC

ORGANISM(S): Homo sapiens

SUBMITTER: perera ranjan 

PROVIDER: S-ECPF-GEOD-15281 | biostudies-other |

REPOSITORIES: biostudies-other