Genomic landscape of meningiomas: gene expression

ABSTRACT: Meningiomas are one of the most common adult brain tumors. For most patients, surgical excision is curative. However, up to 20% recur. Currently, the molecular determinants predicting recurrence and malignant transformation are lacking. We performed global genetic and genomic analysis of 85 meningioma samples of various grades. Copy number alterations were assessed by 100K SNP arrays and correlated with gene expression, proliferation indices, and clinical outcome. In addition to chromosome 22q loss, which was detected in the majority of clinical samples, chromosome 18q and 6q loss significantly predicted recurrence and was associated with anaplastic histology. Five classes of meningiomas were detected by gene expression analysis that correlated with copy number alterations, recurrenc

ORGANISM(S): Homo sapiens

SUBMITTER: Lee Y 

PROVIDER: S-ECPF-GEOD-16581 | biostudies-other | 2010 Jul

REPOSITORIES: biostudies-other