Early Dysregulation of Cell Adhesion and Extracellular Matrix Pathways in Breast Cancer Progression

ABSTRACT: Proliferative breast lesions, such as simple ductal hyperplasia (SH) and atypical ductal hyperplasia (ADH), are candidate precursors to ductal carcinoma in situ (DCIS) and invasive cancer. To better understand their relationship to more advanced disease, we used microdissection and DNA microarrays to profile the gene expression of patient-matched histologically normal (HN), ADH, and DCIS from 12 patients with ER+ sporadic breast cancer. SH were profiled from a subset of cases. We found 837 differentially expressed genes between DCIS-HN and 447 between ADH-HN, with >90% of the ADH-HN genes also present among the DCIS-HN genes. Only 61 genes were identified between ADH-DCIS. Expression differences were reproduced in an independent cohort of patient-matched lesions by qRT-PCR. Many breast can

ORGANISM(S): Homo sapiens

SUBMITTER: Emery LA 

PROVIDER: S-ECPF-GEOD-16873 | biostudies-other | 2009 Sep

REPOSITORIES: biostudies-other