MicroRNA expression analysis in Uveal melanoma from formalin fixed paraffin embedded sections

ABSTRACT: miRNA expression analysis was done on Uveal melanoma, metastatic and non - metastatic case in formalin fixed paraffin embedded sections, identified from case registry and confirmed by Chromosome insitu hybridization harboring monosomy 3 aberration in metastaic case and no aberration in non metastatic case. 19 miRNAs were found to be expressed only in class I tumors (choroidal melanoma) and not in class II (liver metastasis) and 11 miRNAs were found to be expressed only in class II and not in class I. The tumors were found to harbor oncomirs in both choroidal melanoma and metastasizing melanoma targeting tumor suppressor genes and metastatic suppressor genes. None of the differentially expressed miRNAs in either case were found to be located on the chromosomes which have been proved to carr

ORGANISM(S): Homo sapiens

SUBMITTER: Sivamani Sugandan 

PROVIDER: S-ECPF-GEOD-17037 | biostudies-other |

REPOSITORIES: biostudies-other