Expression data from MCF-7 cells transfected with miR-26a and treated or not with estradiol

ABSTRACT: Altered expression of microRNAs (miRNAs), an abundant class of small non-protein-coding RNAs that mostly function as negative regulators of protein-coding gene expression, is common in cancer. Here we analyze the regulation of miRNA expression in response to estrogen, a steroid hormone that is involved in the development and progression of breast carcinomas and that is acting via the estrogen receptors (ER) transcription factors. We set out to thoroughly describe miRNA expression, by using miRNA microarrays and real time RTPCR experiments, in various breast tumor cell lines in which estrogen signaling has been induced by 17β-estradiol (E2). We show that the expression of a broad set of miRNAs decreases following E2 treatment in an ER-dependent manner. We further show that enforced expressi

ORGANISM(S): Homo sapiens

SUBMITTER: Maillot G 

PROVIDER: S-ECPF-GEOD-17460 | biostudies-other | 2009 Nov

REPOSITORIES: biostudies-other