21T series cell lines show distinct stage-specific gene expression alterations

ABSTRACT: Pathologic and epidemiologic evidence has led to a histologic model of breast cancer progression that involves advancement through specific morphologic stages including atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive mammary carcinoma (IMC), although not necessarily always in a linear fashion. Numerous observational studies have examined genetic, epigenetic and gene expression differences in breast tissues representing these different stages of progression, but model systems which would allow for experimental testing of specific factors influencing transition through these stages are scarce. The 21T series cell lines, all originally derived from the same patient with metastatic breast cancer, have been proposed to represent a mammary tumor progression seri

ORGANISM(S): Homo sapiens

SUBMITTER: Souter LH 

PROVIDER: S-ECPF-GEOD-18370 | biostudies-other | 2010 Aug

REPOSITORIES: biostudies-other