Transcription profiling of human breast cancer brain metastases in a mouse xenograft model with vehicle of vorinostat treatment

ABSTRACT: Gene Expression Profiling of a Mouse Xenograft Model of “Triple-Negative” Breast Cancer Brain Metastases With and Without Vorinostat Treatment. Purpose: As chemotherapy and molecular therapy improve the systemic survival of breast cancer patients, the incidence of brain metastases increases. Few therapeutic strategies exist for the treatment of brain metastases because the blood-brain barrier severely limits drug access. We report the pharmacokinetic, efficacy, and mechanism of action studies for the histone deactylase inhibitor vorinostat (suberoylanilide hydroxamic acid) in a preclinical model of brain metastasis of triple-negative breast cancer. Experimental Design: The 231-BR brain trophic subline of the MDA-MB-231 human breast cancer cell line was injected into immunocompromised mice

ORGANISM(S): Homo sapiens

SUBMITTER: Palmieri D 

PROVIDER: S-ECPF-GEOD-18544 | biostudies-other | 2009 Oct

REPOSITORIES: biostudies-other