Mammographic density and genetics - A study of breast biopsies in relation to mammoraphic density

ABSTRACT: Introduction Mammographic density (MD), as assessed from film screen mammograms, is determined by the relative content of adipose, connective and epithelial tissue in the female breast. In epidemiological studies, a high percentage of MD confers a four to six fold risk elevation of developing breast cancer, even after adjustment for other known breast cancer risk factors. However, the biologic correlates of density are little known. Methods Gene expression analysis using whole genome arrays was performed on breast biopsies from 143 women; 79 women with no malignancy (healthy women) and 64 newly diagnosed breast cancer patients, both included from mammographic centres. Percent MD was determined using a previously validated, computerized method on scanned mammograms. Significance analysis o

ORGANISM(S): Homo sapiens

SUBMITTER: Haakensen Vilde 

PROVIDER: S-ECPF-GEOD-18672 | biostudies-other |

REPOSITORIES: biostudies-other