Transcription profiling by array of human non-small cell lung cancer tissue

ABSTRACT: PURPOSE The development of reliable gene expression profiling technology is having an increasing impact on our understanding of lung cancer biology. The present study aims to determine whether the phenotypic heterogeneity and genetic diversity of lung cancer are correlated. PATIENTS AND METHODS In this study, microarray analysis was performed in a set of 91 non-small cell lung cancer (NSCLC) samples in order to: establish gene signatures in primary adenocarcinomas and squamous-cell carcinomas; determine differentially expressed gene sequences at different stages of the disease; and identify sequences with biological significance for tumor progression. After microarray analysis, the expression level of 92 selected genes was validated by qPCR in an independent set of 70 samples. RESULTS Gene

ORGANISM(S): Homo sapiens

SUBMITTER: Sanchez-Palencia A 

PROVIDER: S-ECPF-GEOD-18842 | biostudies-other | 2011 Jul

REPOSITORIES: biostudies-other