A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma

ABSTRACT: The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation, however, instances of CD133- cells exhibiting similar properties have also been reported. Here, we show that some PTEN-deficient GBM tumors produce a series of CD133+ and CD133- self-renewing tumor-initiating cell types and provide evidence that these cell types constitute a lineage hierarchy. Our results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stem-like cells, but can be shared by a lineage of self-renewing cell types expressing a range of markers of forebrain lineage. Keywords: Expression and copy number analysis of glioblastomas and neurosphere forming derivat

ORGANISM(S): Homo sapiens

SUBMITTER: Chen R 

PROVIDER: S-ECPF-GEOD-19612 | biostudies-other | 2010 Apr

REPOSITORIES: biostudies-other