Expression data from different grades (WHO) of astrocytomas (ACM)

ABSTRACT: The aim of the study was to identify significant alterations in genes and molecular functional pathways in comparison with normal and ACM tissue, and detect the marker genes to differentiate the different stage astrocytomas Total RNA was isolated from Seventeen tumor tissue of patients, which included two WHO grade I(T1) and five WHO grade II(T2), III(T3) and IV(T4) samples, and four pooled normal tissue samples. The genome-wide expression analysis was first performed by directly comparing the expression profile of highly enriched different grade astrocytomas and pooled normal tissues, we then applied various data-mining methods to process the 15 different grades tumor tissues sample. Paired T-test and Q-cluster method was performed to explore mark genes validated by qRT-PCR. This study ut

ORGANISM(S): Homo sapiens

SUBMITTER: Yao Zhiqiang 

PROVIDER: S-ECPF-GEOD-19728 | biostudies-other |

REPOSITORIES: biostudies-other