Expression data from parental MDA-MB-231 cells and MDA-MB-231(SA) variant

ABSTRACT: Since bone metastatic breast cancer is an incurable disease, causing significant morbidity and mortality, understanding of the underlying molecular mechanisms would be highly valuable. Here, we describe in vitro and in vivo evidence for the importance of serine biosynthesis in the metastasis of breast cancer to bone. We first characterized the bone metastatic propensity of the MDA-MB-231(SA) cell line variant as compared to the parental MDA-MB-231 cells by radiographic and histological observations in the inoculated mice. Genome-wide gene expression profiling of this isogenic cell line pair revealed that all the three genes involved in the L-serine biosynthesis pathway, phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) we

ORGANISM(S): Homo sapiens

SUBMITTER: Pollari S 

PROVIDER: S-ECPF-GEOD-20085 | biostudies-other | 2011 Jan

REPOSITORIES: biostudies-other