A gene expression signature from peripheral whole blood for stage I lung adenocarcinoma

ABSTRACT: Affordable early screening in subjects with high risk of lung cancer has great potential to improve survival from this deadly disease. We measured gene expression from lung tissue and peripheral whole blood (PWB) from adenocarcinoma cases and controls to identify dysregulated lung cancer genes that could be tested in blood to improve identification of at-risk patients in the future. Genome-wide mRNA expression analysis was conducted in 153 subjects (73 adenocarcinoma cases, 80 controls) from the Environment And Genetics in Lung cancer Etiology (EAGLE) study using PWB and paired snap-frozen tumor and non-involved lung tissue samples. Analyses were conducted using unpaired t-tests, linear mixed effects and ANOVA models. The area under the receiver operating characteristic curve (AUC) was com

ORGANISM(S): Homo sapiens

SUBMITTER: Rotunno M 

PROVIDER: S-ECPF-GEOD-20189 | biostudies-other | 2011 Oct

REPOSITORIES: biostudies-other