YWHAZ is an Invasion and Metastasis promoting genes of Lung cancer

ABSTRACT: Metastasis is a major cause leading to mortality for lung cancer patients. We identified YWHAZ as a potential metastasis-promoting candidate and found that overexpression of YWHAZ promotes lung cancer cell proliferation, anchorage-independent growth, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo. It not only increases cell protrusions and branchings but also induces epithelial-mesenchymal transition. Most importantly, YWHAZ protein could prevent β-catenin from ubiquitination via its association with β-catenin and enhance slug transcriptional activity which is regulated by β-catenin/TCF signaling pathway. Moreover, YWHAZ expression was higher in tumors than in adjacent normal tissues in 63 Non-small-cell lung cancer (NSCLC) patients. NSCLC patients with h

ORGANISM(S): Homo sapiens

SUBMITTER: Chen CH 

PROVIDER: S-ECPF-GEOD-20318 | biostudies-other | 2012 Oct

REPOSITORIES: biostudies-other