Genomics of medulloblastoma identifies four distinct molecular variants

ABSTRACT: Recent genomic approaches have suggested the existence of multiple distinct subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine how many subgroups of the disease exist, how they differ, and the extent of overlap between subgroups. We determined gene expression profiles and DNA copy number aberrations for 103 primary medulloblastomas. Bioinformatic tools were used for class discovery of medulloblastoma subgroups based on the most informative genes in the dataset. Immunohistochemistry for subgroup-specific ‘signature’ genes was used to determine subgroup affiliation for 294 non-overlapping medulloblastomas on two independent tissue microarrays (TMAs). Multiple unsupervised analyses of transcriptional profiles identified four distinct, non-overlapping

ORGANISM(S): Homo sapiens

SUBMITTER: Northcott PA 

PROVIDER: S-ECPF-GEOD-21140 | biostudies-other | 2011 Apr

REPOSITORIES: biostudies-other