18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers

ABSTRACT: Fluorine-18-fluoro-2-deoxy-D-glucose (FDG) is widely used as positron-emission-tomography (PET) radiotracer for the detection and staging of human cancer. Tumor uptake of FDG varies substantially between different cancer types and between patients with the same tumor type. The molecular basis for this heterogeneity is unknown. Using cancer cell lines and primary human tumors of distinct histologic origins, we here show that increased FDG uptake is universally associated with coordinate upregulation of genes within the glycolysis, pentose-phosphate, and other related metabolic pathways. In primary human breast cancers, this FDG signature shows significant overlap with established breast cancer signatures for the “basal-like” disease subtype and “poor prognosis”. FDG high breast cancer sho

ORGANISM(S): Homo sapiens

SUBMITTER: Palaskas N 

PROVIDER: S-ECPF-GEOD-21217 | biostudies-other | 2011 Aug

REPOSITORIES: biostudies-other