Time-dependent expressed markers and their characterization for premature senescence induced by ionizing radiation in MCF7

ABSTRACT: Recently, senescence has been suggested as a defense mechanism to block sporadic induction of cancer cells. Radiation treatment induces proliferating cancer cells to turn into non-proliferating senescent cells in vitro. To characterize transcriptional reprogramming after radiation treatment, we measured the gene expression profiles of MCF7 at different time points after treatment. In these experiments, we found that IR induced premature senescence in MCF7 cells, and IR treatment resulted in significant changes in the expression of 305 marker genes (less than 1% FDR), which were strongly correlated (|r|>0.9) with IR treatment in a time-dependent manner. Functional analysis of these markers indicated that the dynamics of cytoskeletal structure and lysosomal activity gradually increased. The

ORGANISM(S): Homo sapiens

SUBMITTER: Lee Cheol-Koo 

PROVIDER: S-ECPF-GEOD-21748 | biostudies-other |

REPOSITORIES: biostudies-other