Genomic Subtypes of Breast Cancer Identified by Array Comparative Genomic Hybridization

ABSTRACT: Breast cancer is a profoundly heterogeneous disease with respect to biological and clinical behavior. Gene expression profiling has been used to dissect this complexity and stratify tumors into intrinsic gene expression subtypes associated with distinct biology, patient outcome and different genomic alterations. Additionally, breast tumors occurring in individuals with germline BRCA1 or BRCA2 mutations typically fall into distinct subtypes. We applied global DNA copy number and gene expression profiling in 359 breast tumors. All tumors were classified according to intrinsic gene expression subtypes and included cases from genetically predisposed women. The Genomic Identification of Significant Targets in Cancer (GISTIC) algorithm was used to identify significant DNA copy number aberrations

ORGANISM(S): Homo sapiens

SUBMITTER: Borg Åke 

PROVIDER: S-ECPF-GEOD-22133 | biostudies-other |

REPOSITORIES: biostudies-other