Selective Release of miRNA Species from Normal and Malignant Mammary Epithelial Cells

ABSTRACT: MicroRNAs (miRNAs) in body fluids are candidate diagnostics for a variety of conditions and diseases, including breast cancer. One premise for using extracellular miRNAs to diagnose disease is the notion that the abundance of the miRNAs in body fluids reflects their abundance in the abnormal cells causing the disease. As a result, the search for such diagnostics in body fluids has focused on miRNAs that are abundant in the cells of origin. Here we report that released miRNAs do not necessarily reflect the abundance of miRNA in the cell of origin. We find that release of miRNAs from cells into blood, milk and ductal fluids is selective and that the selection of released miRNAs may correlate with malignancy. In particular, the bulk of miR-451 and miR-1246 produced by malignant mammary epithe

ORGANISM(S): Homo sapiens

SUBMITTER: Duelli Dominik 

PROVIDER: S-ECPF-GEOD-22235 | biostudies-other |

REPOSITORIES: biostudies-other