Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer

ABSTRACT: Tamoxifen is the most widely prescribed anti-estrogen treatment for patients with ER-positive breast cancer. However, there is still a need for biomarkers that reliably predict endocrine sensitivity in breast cancers and these may well be expressed in a dynamic manner. In this study we assessed gene expression changes at multiple time points (days 1, 2, 4, 7, 14) after tamoxifen treatment in the ER-positive ZR-75-1 xenograft model that displays significant changes in apoptosis, proliferation and angiogenesis within 2 days of therapy. Hierarchical clustering identified six time-related gene expression patterns, which separated into three groups: two with early/transient responses, two with continuous/late responses and two with variable response patterns. The early/transient response re

ORGANISM(S): Homo sapiens

SUBMITTER: Taylor KJ 

PROVIDER: S-ECPF-GEOD-22386 | biostudies-other | 2010

REPOSITORIES: biostudies-other