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Transcription profiling of human breast cancer cells expressing ERalpha and treated with 17beta-estradiol

ABSTRACT: Gene expression changes caused by estrogen treatment of breast cancer cells that re-express ERalpha was investigated by infecting ER-negative MDA-MB-231 breast cancer cells for 24 h with recombinant adenovirus encoding full-length human ERalpha (Ad-ERalpha) or control vector (Ad-LacZ), and treating them with 0·01% ethanol (vehicle control) or 10-8 M 17beta-estradiol (E2). After 48 h of treatment, total RNA was isolated and used for transcript profiling on Affymetrix GeneChips. Three independent biological replicates of this experiment were carried out.

ORGANISM(S): Homo sapiens

SUBMITTER: Moggs JG 

PROVIDER: S-ECPF-GEOD-2251 | biostudies-other | 2005 Apr

REPOSITORIES: biostudies-other

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