The effect of HES6 silencing on the gene expression profiles of the glioblastoma A172 and LN405 cell lines

ABSTRACT: Malignant glioma is the most common type of primary brain tumor diagnosed annually in 16,000 individuals in the United States. We performed a systematic large-scale transcriptomics data mining study of 9,783 Affymetrix samples from the GeneSapiens database in order to identify those genes that are most glioma-specific as compared to other cancers and normal tissues. We searched for genes that are highly expressed in 322 glioblastoma multiforme tissue samples and 66 anaplastic astrocytomas as compared to 425 samples from histologically normal central nervous system. Transcription cofactor HES6 (Hairy and Enhancer of Split 6) emerged as one of the most glioma-specific genes. In immunostaining of a tissue microarray series, HES6 was expressed in 335 (98.8%) out of the 339 clinical glioma samp

ORGANISM(S): Homo sapiens

SUBMITTER: Haapa-Paananen Saija 

PROVIDER: S-ECPF-GEOD-22692 | biostudies-other |

REPOSITORIES: biostudies-other