Expression data from U373 cells expressing EGFP, MAML1-dn and DTX1-myc

ABSTRACT: Glioblastoma multiforme (GBM) is the most malignant and most common tumor of the central nervous system characterized by rapid growth and extensive tissue infiltration. GBM results in more years of life lost than any other cancer type. Notch signaling has been implicated in GBM pathogenesis through several modes of action. Inhibition of Notch leads to a reduction of cancer-initiating cells in gliomas and reduces proliferation and migration. Deltex1 (DTX1) is part of an alternative Notch signaling pathway distinct from the canonical MAML1/RBP-Jκ-mediated cascade. In this study, we show that DTX1 activates both the RTK/PI3K/PKB as well as the MAPK/ERK pathway. Moreover, we found the anti-apoptotic factor Mcl-1 to be induced by DTX1. In accordance with this, the clonogenic potential and proli

ORGANISM(S): Homo sapiens

SUBMITTER: Huber RM 

PROVIDER: S-ECPF-GEOD-22772 | biostudies-other | 2013

REPOSITORIES: biostudies-other