CHAC1 mRNA expression is a strong prognostic biomarker in breast and ovarian cancer

ABSTRACT: Extracellular, cancer-specific methylated DNA has been shown to be a prognostic marker when detected in serum or plasma. In this study we investigated the effect of treating cancer cells with differentially methylated CpG DNA. When breast cancer cell lines were treated with methylated CpG DNA, a consistent upregulation of CHAC1 mRNA expression was observed. CHAC1 was recently described to be a novel component of the unfolded protein response pathway. To elucidate the role of CHAC1 mRNA expression in cancer in more detail, we analyzed expression of this gene in breast (n=107) and ovarian cancer (n=107) and found a strong correlation with tumor differentiation. Poorly differentiated tumors exhibited higher CHAC1 expression levels (p=0.004 for breast and p=0.031 for ovarian cancer). Additiona

ORGANISM(S): Homo sapiens

SUBMITTER: Goebel G 

PROVIDER: S-ECPF-GEOD-22865 | biostudies-other | 2012 Jan

REPOSITORIES: biostudies-other