Browse
Submit Data
Databases
API
Help

Dataset Information

11 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Circulating miRNAs as biomarkers and potential functional mediators of early stage breast cancer

ABSTRACT: Analysis of the levels of circulating miRNAs from women with early stage breast cancer and matched healthy controls. miRNAs in plasma samples from 20 women with early stage breast cancer (10 Caucasian American and 10 African American) compared with 20 matched healthy controls (10 Caucasian American and 10 African American).

ORGANISM(S): Homo sapiens

SUBMITTER: zhao hua

PROVIDER: S-ECPF-GEOD-22981 | biostudies-other |

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Similar Datasets

Circulating miRNAs as biomarkers and potential functional mediators of early stage breast cancer

Project description:Analysis of the levels of circulating miRNAs from women with early stage breast cancer and matched healthy controls. miRNAs in plasma samples from 20 women with early stage breast cancer (10 Caucasian American and 10 African American) compared with 20 matched healthy controls (10 Caucasian American and 10 African American).

2011-01-16 | E-GEOD-22981 | biostudies-arrayexpress

Circulating miRNAs as biomarkers and potential functional mediators of early stage breast cancer

Project description:Analysis of the levels of circulating miRNAs from women with early stage breast cancer and matched healthy controls.

2011-01-16 | GSE22981 | GEO

A pilot study of circulating miRNAs as potential biomarkers of early stage breast cancer.

Project description: Not available

| S-EPMC2966402 | biostudies-literature

A Signature of Four Circulating microRNAs as Potential Biomarkers for Diagnosing Early-Stage Breast Cancer.

Project description: Not available

| S-EPMC8200990 | biostudies-literature

Circulating ECV-Associated miRNAs as Potential Clinical Biomarkers in Early Stage HBV and HCV Induced Liver Fibrosis.

Project description: Not available

| S-EPMC5298975 | biostudies-literature

Alterations in circulating miRNAs following early-stage breast cancer resection

Project description:Introduction: Circulating microRNAs (miRNAs) exhibit remarkable stability and may serve as biomarkers in several clinical cancer settings. The aim of this study was to investigate changes in the levels of specific circulating miRNA following breast cancer surgery and evaluate whether these alterations were also observed in an independent data set. Methods: Global miRNA analysis was performed on prospectively collected serum samples from 24 post-menopausal women with estrogen receptor-positive early-stage breast cancer before surgery and 3 weeks after tumor resection using global LNA-based quantitative real-time PCR (qPCR). Results: Numbers of specific miRNAs detected in the samples ranged from 142 to 161, with 107 miRNAs detectable in all samples. After correction for multiple comparisons, 3 circulating miRNAs (miR-338-3p, miR-223 and miR-148a) exhibited significantly lower, and 1 miRNA (miR-107) higher levels in post-operative vs. pre-operative samples (p<0.05). No miRNAs were consistently undetectable in the post-operative samples compared to the pre-operative samples. Subsequently, our findings were compared to a dataset from a comparable patient population analyzed using similar study design and the same qPCR profiling platform, resulting in limited agreement. Conclusions: A panel of 4 circulating miRNAs exhibited significantly altered levels following radical resection of primary ER+ breast cancers in post-menopausal women. These specific miRNAs may be involved in tumorigenesis and could potentially be used to monitor whether all cancer cells have been removed at surgery and/or, subsequently, whether the patients develop recurrence. 48 serum samples were prospectively collected from 24 patients with early stage breast cancer before and after surgery at Odense University Hospital. Serum was prepared within one hour of sample collection after centrifugation (2000 x g; 10 min at 20 M-BM-:C) and immediately stored at -80 M-BM-:C.

2014-11-01 | E-GEOD-57661 | biostudies-arrayexpress

Alterations in circulating miRNAs following early-stage breast cancer resection

2014-11-01 | GSE57661 | GEO

Salivary Glycopatterns as Potential Biomarkers for Screening of Early-Stage Breast Cancer.

Project description: Not available

| S-EPMC5898026 | biostudies-literature

Circulating micro-RNAs as potential blood-based markers for early stage breast cancer detection.

Project description: Not available

| S-EPMC3252341 | biostudies-literature

CWRU Circulating miRNAs in Breast Cancer

Project description: Not available

| S-ECPF-GEOD-41526 | biostudies-other