Gene expression profiles of MCF-7 cells treated with Si-Wu-Tang, estradiol and ferulic acid

ABSTRACT: Traditional Chinese medicines (TCM), usually composed of a mixture of components, may simultaneously target multiple genes/pathways and thus achieve superior efficacy for complex diseases such as cancer. To identify novel mechanisms of action and potential health benefits for a TCM formula Si-Wu-Tang (SWT) widely used for women’s health, we obtained the DNA microarray expression profiles for SWT, its active component ferulic acid, and estradiol in human breast cancer cell line MCF-7 and analyzed the gene expression signatures associated with each treatment using the “Connectivity Map” (cMAP). This study indicates that DNA microarray profiling analysis and cMAP data mining provide a powerful approach to discover unknown mechanisms of actions and identify potential new health benefits for TC

ORGANISM(S): Homo sapiens

SUBMITTER: Wen Z 

PROVIDER: S-ECPF-GEOD-23610 | biostudies-other | 2011

REPOSITORIES: biostudies-other