EXPRESSION OF VAV1 IN GLIOBLASTOMA MULTIFORME

ABSTRACT: Background: Even though much progress has been made in the understanding of the molecular nature of glioma, the survival rates of patients affected of this tumour have not changed significantly during these years. Thus, a deeper understanding of this malignancy is still needed in order to predict its outcome and improve patient treatment. Here, we report that VAV1, a GDP/GTP exchange factor for Rho/Rac proteins with oncogenic potential that is involved in the regulation of cytoskeletal dynamics and cell migration. Methodology/Principal Findings: VAV1 is overexpressed in 32 patients diagnosed with high-grade glioma. Such overexpression is linked to the parallel upregulation of a number of genes coding for proteins also involved in cell invasion- and migration-related processes. Unexpectedly

ORGANISM(S): Homo sapiens

SUBMITTER: Garcia Juan 

PROVIDER: S-ECPF-GEOD-24072 | biostudies-other |

REPOSITORIES: biostudies-other