Major gene partners of a favorable biomarker in ER(+) breast cancer

ABSTRACT: Background: We have established a statistical approach on building a transcriptional regulatory network in silico at a global transcriptome scale. Here, we characterize clinical relevant gene activities regulated by a transcription factor-estrogen-related receptor gamma (ESRRG) via such approach. Methods: We measured gene expression relationship between ESRRG and its target gene via univariate coefficient of intrinsic dependence and Galton Pearson’s correlation coefficient. A few more bioinformatics tools were used for further investigation on ESRRG. Results: ESRRG is a negative determinant of lymphovascular invasion, lymph nodal category, stage, histological grade, nuclear pleomorphism and tubule formation in ER(+) infiltrating ductal carcinoma of breast. Interestingly, ESRRG was the o

ORGANISM(S): Homo sapiens

SUBMITTER: Hsieh Fon-Jou 

PROVIDER: S-ECPF-GEOD-24124 | biostudies-other |

REPOSITORIES: biostudies-other