Gene transcription signature of obesity in breast cancer

ABSTRACT: Obesity is thought to contribute to worse disease outcome in breast cancer as a result of increased levels of adipocyte-secreted endocrine factors, insulin, and insulin-like growth factors (IGFs) that accelerate tumor cell proliferation and impair treatment response. We examined the effects of patient obesity on primary breast tumor gene expression, by profiling transcription of a set of tumors for which the patients’ body mass index (BMI) was ascertained. Sample profiles were stratified according to patients’ obesity phenotype defined as normal (BMI <25), overweight (BMI 25-29.9), or obese (BMI>30). Widespread alterations in gene expression were evident in breast tumors from obese patients as compared to tumors from other patients, allowing us to define an obesity-associated cancer trans

ORGANISM(S): Homo sapiens

SUBMITTER: Creighton CJ 

PROVIDER: S-ECPF-GEOD-24185 | biostudies-other | 2012 Apr

REPOSITORIES: biostudies-other