Molecular signature of CD8+ T cell exhaustion in metastases but not in peripheral blood from melanoma patients

ABSTRACT: In chronic viral infections such as HIV-1, HBV and HCV, CD8+ T cells may become ”exhausted”, characterized by progressive functional deficiency. Recently, the underlying mechanisms have been characterized by molecular profiling of virus-specific CD8+ T cells. In contrast, only little is known of self/tumor-specific CD8+ T cells from cancer patients, likely because they are much more difficult to assess. For the first time, we determined the molecular profile of human tumor-specific CD8+ T cells, upon sorting of Melan-A/MART-1 specific T cells directly ex vivo from 19 melanoma patients after vaccination with peptide and CpG. For comparison, we sorted protective T cells specific for the two herpes viruses EBV and CMV. In peripheral blood, we found multiple features of functional effector T

ORGANISM(S): Homo sapiens

SUBMITTER: Baitsch L 

PROVIDER: S-ECPF-GEOD-24536 | biostudies-other | 2011 Jun

REPOSITORIES: biostudies-other