Large scale screening for known fusion genes in cancer cell lines

ABSTRACT: We have utilized a version 2.0 of our Fusion gene microarray (version 1.0 described by PMID: 19152679 and GEO, GPL8078) to screen cancer cell lines for known fusion genes We assembled a comprehensive database of published fusion genes, including those which have been reported only in individual studies and samples, and fusion genes resulting from deep sequencing of cancer genomes and transcriptomes. From the total set of 548 fusion genes, we designed 197,846 unique oligonucleotides, targeting both chimeric transcript junctions as well as sequences internal to each of the fusion gene partners. We investigated the presence of fusion genes in a series of 67 cell lines originating from 15 different cancer types. Data from ten leukaemia cell lines with known fusion gene status were used to eval

ORGANISM(S): Homo sapiens

SUBMITTER: Løvf M 

PROVIDER: S-ECPF-GEOD-24737 | biostudies-other | 2011 May

REPOSITORIES: biostudies-other