Response of A549 cells treated with Aspergillus fumigatus [WT-GC_vs_PrtT-GC]

ABSTRACT: Response of A549 cells treated with Aspergillus fumigatus wild type germinating conidia (WT_GC) or PrtT protease deficient mutant conidia (PrtT-GC) or inert acrylic 2-4 micron beads (Beads) for 8h Aspergillus fumigatus is the most commonly encountered mold pathogen of humans, predominantly infecting the respiratory system. Colonization and penetration of the lung alveolar epithelium is a key but poorly understood step in the infection process. This study focused on identifying the transcriptional and cell-signaling responses activated in A549 alveolar carcinoma cells incubated in the presence of A. fumigatus wild-type and ΔPrtT protease-deficient germinating conidia and culture filtrates (CF). Microarray analysis of exposed A549 cells identified distinct classes of genes whose expression i

ORGANISM(S): Homo sapiens

SUBMITTER: Sharon Haim 

PROVIDER: S-ECPF-GEOD-24984 | biostudies-other |

REPOSITORIES: biostudies-other