Gene expression profiles of ovarian cancer cell lines in the presence and absence of a DNA methyltransferase inhibitor

ABSTRACT: Epithelial ovarian cancer is the leading cause of death among gynecologic malignancies. Diagnosis usually occurs after metastatic spread, largely reflecting vague symptoms of early disease combined with lack of an effective screening strategy. Epigenetic mechanisms of gene regulation, including DNA methylation, are fundamental to normal cellular function and also play a major role in carcinogenesis. To elucidate the biological and clinical relevance of DNA methylation in ovarian cancer, we conducted expression microarray analysis of 43 cell lines and 17 primary culture specimens grown in the presence or absence of DNA methyltransferase (DNMT) inhibitors. Two parameters, induction of expression and standard deviation among untreated samples, identified 378 candidate methylated genes, many

ORGANISM(S): Homo sapiens

SUBMITTER: Murphy Susan 

PROVIDER: S-ECPF-GEOD-25428 | biostudies-other |

REPOSITORIES: biostudies-other