Expression profiles of CD24-/CD44+/ESA+ population in MDA-MB-231 and its highly metastatic variants

ABSTRACT: Breast cancer is a curable disease if it is diagnosed at an early stage. However, only little options are left once the tumor is metastasized to distant organs, and more than 90% of breast cancer death is attributed to metastatic disease. The process of metastasis is highly complex and involves many steps for successful colonization of tumor cells at a target organ. According to the cancer stem cell (CSC) theory, which still remains a hypothesis, these metastatic cells must have stem cell-like capability for their self-renewal in addition to their invasive ability. Therefore, it has been predicted that a “metastatic stem cell”, which is distinct from a cancer stem cell, must exist in the primary tumor mass. To identify genes that are involved in metastasis of CSCs, we isolated CSC popul

ORGANISM(S): Homo sapiens

SUBMITTER: Okuda Hiroshi 

PROVIDER: S-ECPF-GEOD-25976 | biostudies-other |

REPOSITORIES: biostudies-other