Identification of genes upregulated by MeTA-array in human pancreatic cancers

ABSTRACT: Identification and characterization of epigenetically silenced genes is very important for cancer research. Particularly, information of hypermethylated genes provides clues to understand roles of epigenetics in tumorigeneses, and genes frequently methylated in a tumor-specific manner can be used as tumor markers. DNA methylation inhibitors such as 5-aza-cytidine or 5-aza-2’-deoxycytidine were widely used to search epigenetically silenced genes. However, these inhibitors frequently upregulate genes whose promoters remain unmethylated. We tried to improve the specificity and sensitivity in detecting such methylation-mediated silenced genes in cancer and successfully developed a new method termed “methyl-CpG targeted transcriptional activation (MeTA)” by using a transcriptional activating fr

ORGANISM(S): Homo sapiens

SUBMITTER: Shimizu H 

PROVIDER: S-ECPF-GEOD-26215 | biostudies-other | 2011 Jul

REPOSITORIES: biostudies-other