Differentiation Score and Intrinsic Subtype Predict Breast Cancer Organ of Relapse

ABSTRACT: The ability to predict metastatic potential is of clinical and biological importance. Numerous metastasis/relapse predictors exist for breast cancer patients; however, what is less well established is whether predicting metastasis to specific organs sites is feasible. In this study we sought to determine: 1) the degree to which gene signatures vary across tumors and their metastases, 2) if genomic intrinsic subtypes associate with particular organs of relapse, and 3) if other genomic signatures can predict spread to specific organs. Using a gene expression microarray data set of >1000 breast tumors and metastases, we observed that >90% of 298 gene signatures were similarly expressed between matched pairs of breast tumors and metastases; those most altered were reflective of cell types inc

ORGANISM(S): Homo sapiens

SUBMITTER: Harrell JC 

PROVIDER: S-ECPF-GEOD-26338 | biostudies-other | 2012 Apr

REPOSITORIES: biostudies-other